Ontology highlight
ABSTRACT:
SUBMITTER: Kim IH
PROVIDER: S-EPMC4513127 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Kim In Hwang IH Kim Ik-Jung IJ Wen Yancheng Y Park Na-Young NY Park Jinyoung J Lee Keun-Woo KW Koh Ara A Lee Ji-Hyun JH Koo Seung-Hoi SH Kim Kun-Soo KS
The Journal of biological chemistry 20150603 30
We describe a novel insulin-degrading enzyme, SidC, that contributes to the proliferation of the human bacterial pathogen Vibrio vulnificus in a mouse model. SidC is phylogenetically distinct from other known insulin-degrading enzymes and is expressed and secreted specifically during host infection. Purified SidC causes a significant decrease in serum insulin levels and an increase in blood glucose levels in mice. A comparison of mice infected with wild type V. vulnificus or an isogenic sidC-del ...[more]