Ontology highlight
ABSTRACT:
SUBMITTER: Forsberg KJ
PROVIDER: S-EPMC4515146 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Chemistry & biology 20150618 7
Enzymes capable of inactivating tetracycline are paradoxically rare compared with enzymes that inactivate other natural-product antibiotics. We describe a family of flavoenzymes, previously unrecognizable as resistance genes, which are capable of degrading tetracycline antibiotics. From soil functional metagenomic selections, we discovered nine genes that confer high-level tetracycline resistance by enzymatic inactivation. We also demonstrate that a tenth enzyme, an uncharacterized homolog in th ...[more]