Ontology highlight
ABSTRACT:
SUBMITTER: Gasparrini AJ
PROVIDER: S-EPMC7229144 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gasparrini Andrew J AJ Markley Jana L JL Kumar Hirdesh H Wang Bin B Fang Luting L Irum Sidra S Symister Chanez T CT Wallace Meghan M Burnham Carey-Ann D CD Andleeb Saadia S Tolia Niraj H NH Wencewicz Timothy A TA Dantas Gautam G
Communications biology 20200515 1
Tetracycline resistance by antibiotic inactivation was first identified in commensal organisms but has since been reported in environmental and pathogenic microbes. Here, we identify and characterize an expanded pool of tet(X)-like genes in environmental and human commensal metagenomes via inactivation by antibiotic selection of metagenomic libraries. These genes formed two distinct clades according to habitat of origin, and resistance phenotypes were similarly correlated. Each gene isolated fro ...[more]