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Tetracycline-Inactivating Enzymes.

ABSTRACT: Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis and strategic scaffold modifications designed to overcome established clinical resistance mechanisms including efflux and ribosome protection. Emerging new resistance mechanisms, including enzymatic antibiotic inactivation, threaten recent progress on bringing these next-generation tetracyclines to the clinic. Here we review the current state of knowledge on the structure, mechanism, and inhibition of tetracycline-inactivating enzymes.

SUBMITTER: Markley JL

PROVIDER: S-EPMC5988894 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Tetracycline-Inactivating Enzymes.

Markley Jana L JL Wencewicz Timothy A TA

Frontiers in microbiology 20180530

Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis and strategic scaffold modifications designed to overcome established clinical resistance mechanisms including efflux and ribosome protection. Emerging new resistance mechanisms, including enzymatic antibiotic inactivation, threaten recent progress on bringing these next-generation tetracyclines to the clinic. Her ...[more]

PMID: 29899733

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