Ontology highlight
ABSTRACT:
SUBMITTER: Markley JL
PROVIDER: S-EPMC5988894 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in microbiology 20180530
Tetracyclines have been foundational antibacterial agents for more than 70 years. Renewed interest in tetracycline antibiotics is being driven by advancements in tetracycline synthesis and strategic scaffold modifications designed to overcome established clinical resistance mechanisms including efflux and ribosome protection. Emerging new resistance mechanisms, including enzymatic antibiotic inactivation, threaten recent progress on bringing these next-generation tetracyclines to the clinic. Her ...[more]