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Tumor-Associated Glycans and Immune Surveillance.

ABSTRACT: Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that bridge innate immune surveillance and adaptive antitumor immunity in clinical applications. T-cells, being a part of the adaptive immune response, are the most popular component of the immune system considered for targeting tumor cells. However, for TACAs, T-cells take a back seat to antibodies and natural killer cells as first-line innate defense mechanisms. Here, we briefly highlight the rationale associated with the relative importance of the immune surveillance machinery that might be applicable for developing therapeutics.

SUBMITTER: Monzavi-Karbassi B

PROVIDER: S-EPMC4515579 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Tumor-Associated Glycans and Immune Surveillance.

Monzavi-Karbassi Behjatolah B Pashov Anastas A Kieber-Emmons Thomas T

Vaccines 20130617 2

Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that bridge innate immune surveillance and adaptive antitumor immunity in clinical applications. T-cells, being a part of the adaptive immune response, are the most popular component of the immune system considered for targeting tumor cells. However, ...[more]

PMID: 26343966

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