Ontology highlight
ABSTRACT:
SUBMITTER: Monzavi-Karbassi B
PROVIDER: S-EPMC4515579 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Monzavi-Karbassi Behjatolah B Pashov Anastas A Kieber-Emmons Thomas T
Vaccines 20130617 2
Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that bridge innate immune surveillance and adaptive antitumor immunity in clinical applications. T-cells, being a part of the adaptive immune response, are the most popular component of the immune system considered for targeting tumor cells. However, ...[more]