Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC7816704 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Li Hui H Kuang Xinwei X Liang Long L Ye Youqiong Y Zhang YongChang Y Li Jialu J Ma Fangyu F Tao Juan J Lei Guang G Zhao Shuang S Su Juan J Yang Nong N Peng Cong C Xu Xiaowei X Hung Mien-Chie MC Han Leng L Liu Hong H Liu Jing J Chen Xiang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20201127 2
Immune checkpoints blockades have shown promising clinical effects in various malignancies, but the overall response rate is low. Here, the immune features are comprehensively characterized in >10 000 cancer patients from The Cancer Genome Atlas and significantly positive correlations are observed between targets of Sunitinib and inhibitory immune checkpoints and suppressive immune cells. It is further confirmed that Sunitinib treatment increases the antitumor immunity in a phase III trial. Mech ...[more]