Ontology highlight
ABSTRACT:
SUBMITTER: Bruschi M
PROVIDER: S-EPMC4520170 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bruschi Maurizio M Galetti Maricla M Sinico Renato Alberto RA Moroni Gabriella G Moroni Gabriella G Bonanni Alice A Radice Antonella A Tincani Angela A Pratesi Federico F Migliorini Paola P Murtas Corrado C Franceschini Franco F Trezzi Barbara B Brunini Francesca F Gatti Rita R Tardanico Regina R Barbano Giancarlo G Piaggio Giorgio G Messa Piergiorgio P Ravani Pietro P Scolari Francesco F Candiano Giovanni G Martini Alberto A Allegri Landino L Ghiggeri Gian Marco GM
Journal of the American Society of Nephrology : JASN 20141114 8
Glomerular planted antigens (histones, DNA, and C1q) are potential targets of autoimmunity in lupus nephritis (LN). However, the characterization of these antigens in human glomeruli in vivo remains inconsistent. We eluted glomerular autoantibodies recognizing planted antigens from laser-microdissected renal biopsy samples of 20 patients with LN. Prevalent antibody isotypes were defined, levels were determined, and glomerular colocalization was investigated. Renal and circulating antibodies were ...[more]