Ontology highlight
ABSTRACT:
SUBMITTER: Mori G
PROVIDER: S-EPMC4521081 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Mori Giorgia G Chiarelli Laurent R LR Esposito Marta M Makarov Vadim V Bellinzoni Marco M Hartkoorn Ruben C RC Degiacomi Giulia G Boldrin Francesca F Ekins Sean S de Jesus Lopes Ribeiro Ana Luisa AL Marino Leonardo B LB Centárová Ivana I Svetlíková Zuzana Z Blaško Jaroslav J Kazakova Elena E Lepioshkin Alexander A Barilone Nathalie N Zanoni Giuseppe G Porta Alessio A Fondi Marco M Fani Renato R Baulard Alain R AR Mikušová Katarína K Alzari Pedro M PM Manganelli Riccardo R de Carvalho Luiz Pedro S LP Riccardi Giovanna G Cole Stewart T ST Pasca Maria Rosalia MR
Chemistry & biology 20150618 7
To combat the emergence of drug-resistant strains of Mycobacterium tuberculosis, new antitubercular agents and novel drug targets are needed. Phenotypic screening of a library of 594 hit compounds uncovered two leads that were active against M. tuberculosis in its replicating, non-replicating, and intracellular states: compounds 7947882 (5-methyl-N-(4-nitrophenyl)thiophene-2-carboxamide) and 7904688 (3-phenyl-N-[(4-piperidin-1-ylphenyl)carbamothioyl]propanamide). Mutants resistant to both compou ...[more]