Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.

ABSTRACT:

Rationale

PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. However, it is unclear whether genome-wide association studies-identified coronary artery disease genes, including PPAP2B, participate in mechanotransduction mechanisms by which vascular endothelia respond to local atherorelevant hemodynamics that contribute to the regional nature of atherosclerosis.

Objective

To establish the critical role of PPAP2B in endothelial responses to hemodynamics.

Methods and results

Reduced PPAP2B was detected in vivo in mouse and swine aortic arch (AA) endothelia exposed to chronic distur

SUBMITTER: Wu C 

PROVIDER: S-EPMC4522239 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature