Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.
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ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC4528943 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.
Huang Ji J Malhi Manpreet M Deneke Jan J Fraser Marie Elizabeth ME
Acta crystallographica. Section F, Structural biology communications 20150729 Pt 8
Pig GTP-specific succinyl-CoA synthetase is an αβ-heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 Å resolution. The structure shows CoA bound to the amino-terminal domain of the α-subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides. ...[more]
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