Impact of the DNA polymerase Theta on the DNA replication program.
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ABSTRACT:
SUBMITTER: Baldacci G
PROVIDER: S-EPMC4535461 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Impact of the DNA polymerase Theta on the DNA replication program.
Baldacci Giuseppe G Hoffmann Jean-Sebastien JS Cadoret Jean-Charles JC
Genomics data 20141205
The physiological function of the human DNA polymerase θ (pol θ) is still unclear despite its in vitro translesion synthesis capacity during DNA damage repair process. However this DNA polymerase is always present along the cell cycle in the absence of replication stress and DNA damage. Is there a different molecular function? We present the genomic data of replication timing in depleted pol θ cells (GSE49693) and in cells overexpressing pol θ (GSE53070) indicating that Pol θ holds a novel role ...[more]
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