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Impact of the DNA polymerase Theta on the DNA replication program.

ABSTRACT: The physiological function of the human DNA polymerase ? (pol ?) is still unclear despite its in vitro translesion synthesis capacity during DNA damage repair process. However this DNA polymerase is always present along the cell cycle in the absence of replication stress and DNA damage. Is there a different molecular function? We present the genomic data of replication timing in depleted pol ? cells (GSE49693) and in cells overexpressing pol ? (GSE53070) indicating that Pol ? holds a novel role in the absence of external stress as a critical determinant of the replication timing program in human cells.

SUBMITTER: Baldacci G

PROVIDER: S-EPMC4535461 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Impact of the DNA polymerase Theta on the DNA replication program.

Baldacci Giuseppe G Hoffmann Jean-Sebastien JS Cadoret Jean-Charles JC

Genomics data 20141205

The physiological function of the human DNA polymerase θ (pol θ) is still unclear despite its in vitro translesion synthesis capacity during DNA damage repair process. However this DNA polymerase is always present along the cell cycle in the absence of replication stress and DNA damage. Is there a different molecular function? We present the genomic data of replication timing in depleted pol θ cells (GSE49693) and in cells overexpressing pol θ (GSE53070) indicating that Pol θ holds a novel role ...[more]

PMID: 26484154

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