Multifaceted Nature of DNA Polymerase θ.
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ABSTRACT:
SUBMITTER: Kruchinin AA
PROVIDER: S-EPMC9962433 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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Multifaceted Nature of DNA Polymerase θ.
Kruchinin Alexander A AA Makarova Alena V AV
International journal of molecular sciences 20230210 4
DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this review, we discuss unique biochemical properties and structural features of Pol θ, its multiple roles in protection of genome stability and the potential of Pol θ as a target for cancer treatment. ...[more]
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