Ontology highlight
ABSTRACT:
SUBMITTER: Morris RW
PROVIDER: S-EPMC4538266 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Morris Richard W RW Taylor Amy E AE Fluharty Meg E ME Bjørngaard Johan H JH Åsvold Bjørn Olav BO Elvestad Gabrielsen Maiken M Campbell Archie A Marioni Riccardo R Kumari Meena M Korhonen Tellervo T Männistö Satu S Marques-Vidal Pedro P Kaakinen Marika M Cavadino Alana A Postmus Iris I Husemoen Lise Lotte N LL Skaaby Tea T Ahluwalia Tarun Veer Singh TV Treur Jorien L JL Willemsen Gonneke G Dale Caroline C Wannamethee S Goya SG Lahti Jari J Palotie Aarno A Räikkönen Katri K McConnachie Alex A Padmanabhan Sandosh S Wong Andrew A Dalgård Christine C Paternoster Lavinia L Ben-Shlomo Yoav Y Tyrrell Jessica J Horwood John J Fergusson David M DM Kennedy Martin A MA Nohr Ellen A EA Christiansen Lene L Kyvik Kirsten Ohm KO Kuh Diana D Watt Graham G Eriksson Johan G JG Whincup Peter H PH Vink Jacqueline M JM Boomsma Dorret I DI Davey Smith George G Lawlor Debbie D Linneberg Allan A Ford Ian I Jukema J Wouter JW Power Chris C Hyppönen Elina E Jarvelin Marjo-Riitta MR Preisig Martin M Borodulin Katja K Kaprio Jaakko J Kivimaki Mika M Smith Blair H BH Hayward Caroline C Romundstad Pål R PR Sørensen Thorkild I A TI Munafò Marcus R MR Sattar Naveed N
BMJ open 20150811 8
<h4>Objectives</h4>To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.<h4>Design</h4>Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.<h4>Participants</h4>148,731 curren ...[more]