Ontology highlight
ABSTRACT:
SUBMITTER: Chiappini C
PROVIDER: S-EPMC4538992 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nature materials 20150330 5
The controlled delivery of nucleic acids to selected tissues remains an inefficient process mired by low transfection efficacy, poor scalability because of varying efficiency with cell type and location, and questionable safety as a result of toxicity issues arising from the typical materials and procedures employed. High efficiency and minimal toxicity in vitro has been shown for intracellular delivery of nuclei acids by using nanoneedles, yet extending these characteristics to in vivo delivery ...[more]