Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation.
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ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC4710492 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation.
Zhang Chuan C Hao Liangliang L Calabrese Colin M CM Zhou Yu Y Choi Chung Hang J CH Xing Hang H Mirkin Chad A CA
Small (Weinheim an der Bergstrasse, Germany) 20150821 40
By grafting multiple DNA strands onto one terminus of a polyester chain, a DNA-brush block copolymer that can assemble into micelle structure is constructed. These micelle spherical nucleic acids have a density of nucleic acids that is substantively higher than linear DNA block copolymer structures, which makes them effective cellular transfection and intracellular gene regulation agents. ...[more]
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