Nicotinic receptor contributions to smoking: insights from human studies and animal models.
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ABSTRACT:
SUBMITTER: Brunzell DH
PROVIDER: S-EPMC4540370 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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Nicotinic receptor contributions to smoking: insights from human studies and animal models.
Brunzell Darlene H DH Stafford Alexandra M AM Dixon Claire I CI
Current addiction reports 20150301 1
It is becoming increasingly evident that a variety of factors contribute to smoking behavior. Nicotine is a constituent of tobacco smoke that exerts its psychoactive effects via binding to nicotinic acetylcholine receptors (nAChRs) in brain. Human genetic studies have identified polymorphisms in nAChR genes, which predict vulnerability to risk for tobacco dependence. <i>In vitro</i> studies and animal models have identified the functional relevance of specific polymorphisms. Together with animal ...[more]
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