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DNA methylation and childhood maltreatment: from animal models to human studies.

ABSTRACT: Childhood maltreatment (CM) has estimated prevalence among Western societies between 10% and 15%. As CM associates with increased risk of several psychiatric disorders, early age of illness onset, increased comorbidity and negative clinical outcome, it imposes a major public health, social and economic impact. Although the clinical consequences of CM are well characterized, a major challenge remains to understand how negative early-life events can affect brain function over extended periods of time. We review here both animal and human studies indicating that the epigenetic mechanism of DNA methylation is a crucial mediator of early-life experiences, thereby maintaining life-long neurobiological sequelae of CM, and strongly determining psychopathological risk.

SUBMITTER: Lutz PE

PROVIDER: S-EPMC5293537 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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DNA methylation and childhood maltreatment: from animal models to human studies.

Lutz P-E PE Turecki G G

Neuroscience 20130808

Childhood maltreatment (CM) has estimated prevalence among Western societies between 10% and 15%. As CM associates with increased risk of several psychiatric disorders, early age of illness onset, increased comorbidity and negative clinical outcome, it imposes a major public health, social and economic impact. Although the clinical consequences of CM are well characterized, a major challenge remains to understand how negative early-life events can affect brain function over extended periods of t ...[more]

PMID: 23933308

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