Ontology highlight
ABSTRACT:
SUBMITTER: McKerrell T
PROVIDER: S-EPMC4542313 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
McKerrell Thomas T Park Naomi N Moreno Thaidy T Grove Carolyn S CS Ponstingl Hannes H Stephens Jonathan J Crawley Charles C Craig Jenny J Scott Mike A MA Hodkinson Clare C Baxter Joanna J Rad Roland R Forsyth Duncan R DR Quail Michael A MA Zeggini Eleftheria E Ouwehand Willem W Varela Ignacio I Vassiliou George S GS
Cell reports 20150226 8
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequencing. Using only the hot spots studied, we identified clonal hemopoiesis in 0.8% of individuals under 60, rising to 19.5% of those ≥90 years, thus predicting that clonal hemopoiesis is much more prevalent than previously realized. DNMT3A-R882 mutations were m ...[more]