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Synthesis of a reactive oxygen species responsive heterobifunctional thioketal linker.

ABSTRACT: A new heterobifunctional reactive oxygen species (ROS) responsive thioketal linker and its synthesis are described. This linker allows for developing new ROS-responsive agents with two distinct functionalities using universal bioconjugation methods. The reaction kinetics of the thioketal cleavage in the presence of ROS is also described.

SUBMITTER: Ling X 

PROVIDER: S-EPMC4545510 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Synthesis of a reactive oxygen species responsive heterobifunctional thioketal linker.

Ling Xiaoxi X   Zhang Shaojuan S   Shao Pin P   Wang Pengcheng P   Ma Xiaochao X   Bai Mingfeng M  

Tetrahedron letters 20150901 37

A new heterobifunctional reactive oxygen species (ROS) responsive thioketal linker and its synthesis are described. This linker allows for developing new ROS-responsive agents with two distinct functionalities using universal bioconjugation methods. The reaction kinetics of the thioketal cleavage in the presence of ROS is also described. ...[more]

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