Ontology highlight
ABSTRACT:
SUBMITTER: Lancioni C
PROVIDER: S-EPMC3297089 | biostudies-other | 2012 Jan
REPOSITORIES: biostudies-other
Lancioni Christina C Nyendak Melissa M Kiguli Sarah S Zalwango Sarah S Mori Tomi T Mayanja-Kizza Harriet H Balyejusa Stephen S Null Megan M Baseke Joy J Mulindwa Deo D Byrd Laura L Swarbrick Gwendolyn G Scott Christine C Johnson Denise F DF Malone LaShaunda L Mudido-Musoke Philipa P Boom W Henry WH Lewinsohn David M DM Lewinsohn Deborah A DA
American journal of respiratory and critical care medicine 20111027 2
<h4>Rationale</h4>The immunologic events surrounding primary Mycobacterium tuberculosis infection and development of tuberculosis remain controversial. Young children who develop tuberculosis do so quickly after first exposure, thus permitting study of immune response to primary infection and disease. We hypothesized that M. tuberculosis-specific CD8(+) T cells are generated in response to high bacillary loads occurring during tuberculosis.<h4>Objectives</h4>To determine if M. tuberculosis-speci ...[more]