The successful search for genetic loci associated with depression.
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ABSTRACT:
SUBMITTER: Rivera M
PROVIDER: S-EPMC4548917 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
The successful search for genetic loci associated with depression.
Rivera Margarita M McGuffin Peter P
Genome medicine 20150825
Major depressive disorder is among the leading causes of disease burden and disability, as well as a major public health concern worldwide. Despite its substantial heritability, no robustly replicated genetic risk loci had been found until recently. Now, a new study has identified, and replicated, two variants associated with an increased risk for this disorder. The success of this study appears to lie in the use of low-coverage sequencing, instead of microarrays, and in minimizing phenotypic an ...[more]
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