A common glycan structure on immunoglobulin G for enhancement of effector functions.
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ABSTRACT:
SUBMITTER: Lin CW
PROVIDER: S-EPMC4553773 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
A common glycan structure on immunoglobulin G for enhancement of effector functions.
Lin Chin-Wei CW Tsai Ming-Hung MH Li Shiou-Ting ST Tsai Tsung-I TI Chu Kuo-Ching KC Liu Ying-Chih YC Lai Meng-Yu MY Wu Chia-Yu CY Tseng Yung-Chieh YC Shivatare Sachin S SS Wang Chia-Hung CH Chao Ping P Wang Shi-Yun SY Shih Hao-Wei HW Zeng Yi-Fang YF You Tsai-Hong TH Liao Jung-Yu JY Tu Yu-Chen YC Lin Yih-Shyan YS Chuang Hong-Yang HY Chen Chia-Lin CL Tsai Charng-Sheng CS Huang Chiu-Chen CC Lin Nan-Horng NH Ma Che C Wu Chung-Yi CY Wong Chi-Huey CH
Proceedings of the National Academy of Sciences of the United States of America 20150807 34
Antibodies have been developed as therapeutic agents for the treatment of cancer, infection, and inflammation. In addition to binding activity toward the target, antibodies also exhibit effector-mediated activities through the interaction of the Fc glycan and the Fc receptors on immune cells. To identify the optimal glycan structures for individual antibodies with desired activity, we have developed an effective method to modify the Fc-glycan structures to a homogeneous glycoform. In this study, ...[more]
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