Purinergic Enhancement of Anti-Leishmanial Effector Functions of Neutrophil Granulocytes.

ABSTRACT: Although macrophages are considered for host cells for the multiplication of Leishmania, recent studies indicate the important role of neutrophil granulocytes as host cells for these intracellular parasites. Neutrophils have been shown to be massively and rapidly recruited to the site of Leishmania infection where they represent the first cells to encounter the parasites. Exposure to ATP and UTP have been shown to enhance anti-Leishmania activity of macrophages and intralesional injection of UTP led to strongly reduced parasite load in vivo. Since the in vivo anti-leishmanial effect of extracellular UTP correlated with enhanced neutrophil recruitment and enhanced ROS production at the site of Leishmania infection we hypothesized that exposure to ex

SUBMITTER: Moller S 

PROVIDER: S-EPMC8558537 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature