Ontology highlight
ABSTRACT:
SUBMITTER: Patel SK
PROVIDER: S-EPMC4554801 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Patel Sravan Kumar SK Beaino Wissam W Anderson Carolyn J CJ Janjic Jelena M JM
Clinical immunology (Orlando, Fla.) 20150508 1
Targeting macrophages for therapeutic and diagnostic purposes is an attractive approach applicable to multiple diseases. Here, we present a theranostic nanoemulsion platform for simultaneous delivery of an anti-inflammatory drug (celecoxib) to macrophages and monitoring of macrophage migration patterns by optical imaging, as measurement of changes in inflammation. The anti-inflammatory effect of the theranostic nanoemulsions was evaluated in a mouse inflammation model induced with complete Freun ...[more]