Breast cancer risk and imprinting methylation in blood.

ABSTRACT:

Background

Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, providing a plausible mechanism linking known early life factors to cancer risk. This study investigated methylation status of seven imprinted differentially methylated regions-PLAGL1/ZAC1, H19-ICR1, IGF2-DMR2, KvDMR-ICR2, RB1, SNRPN-DMR1 and PEG3-in blood samples from 189 women with the most common type of invasive breast cancer (invasive ductal carcinoma-IDC), 41 women with in situ breast cancer (ductal carcinoma in situ-DCIS) and 363 matched disease-free controls.

Results

There was no evidence that imprinted gene methylation levels varied with age (between 25

SUBMITTER: Harrison K 

PROVIDER: S-EPMC4560070 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature