Ontology highlight
ABSTRACT:
SUBMITTER: Ivanov S
PROVIDER: S-EPMC4811132 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ivanov Stoyan S Scallan Joshua P JP Kim Ki-Wook KW Werth Kathrin K Johnson Michael W MW Saunders Brian T BT Wang Peter L PL Kuan Emma L EL Straub Adam C AC Ouhachi Melissa M Weinstein Erica G EG Williams Jesse W JW Briseño Carlos C Colonna Marco M Isakson Brant E BE Gautier Emmanuel L EL Förster Reinhold R Davis Michael J MJ Zinselmeyer Bernd H BH Randolph Gwendalyn J GJ
The Journal of clinical investigation 20160321 4
Lymphatic collecting vessels direct lymph into and from lymph nodes (LNs) and can become hyperpermeable as the result of a previous infection. Enhanced permeability has been implicated in compromised immunity due to reduced flow of lymph and immune cells to LNs, which are the primary site of antigen presentation to T cells. Presently, very little is known about the molecular signals that affect lymphatic collecting vessel permeability. Here, we have shown that lymphatic collecting vessel permeab ...[more]