Ontology highlight
ABSTRACT:
SUBMITTER: Kuan EL
PROVIDER: S-EPMC4433841 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kuan Emma L EL Ivanov Stoyan S Bridenbaugh Eric A EA Victora Gabriel G Wang Wei W Childs Ed W EW Platt Andrew M AM Jakubzick Claudia V CV Mason Robert J RJ Gashev Anatoliy A AA Nussenzweig Michel M Swartz Melody A MA Dustin Michael L ML Zawieja David C DC Randolph Gwendalyn J GJ
Journal of immunology (Baltimore, Md. : 1950) 20150427 11
Collecting lymphatic vessels (CLVs), surrounded by fat and endowed with contractile muscle and valves, transport lymph from tissues after it is absorbed into lymphatic capillaries. CLVs are not known to participate in immune responses. In this study, we observed that the inherent permeability of CLVs allowed broad distribution of lymph components within surrounding fat for uptake by adjacent macrophages and dendritic cells (DCs) that actively interacted with CLVs. Endocytosis of lymph-derived Ag ...[more]