Ontology highlight
ABSTRACT:
SUBMITTER: Besnier LS
PROVIDER: S-EPMC4569320 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Besnier Laura S LS Cardot Philippe P Da Rocha Barbara B Simon Anthony A Loew Damarys D Klein Christophe C Riveau Béatrice B Lacasa Michel M Clair Caroline C Rousset Monique M Thenet Sophie S
Molecular biology of the cell 20150729 18
We reported previously that the cellular prion protein (PrP(c)) is a component of desmosomes and contributes to the intestinal barrier function. We demonstrated also the presence of PrP(c) in the nucleus of proliferating intestinal epithelial cells. Here we sought to decipher the function of this nuclear pool. In human intestinal cancer cells Caco-2/TC7 and SW480 and normal crypt-like HIEC-6 cells, PrP(c) interacts, in cytoplasm and nucleus, with γ-catenin, one of its desmosomal partners, and wi ...[more]