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G protein-coupled odorant receptors: From sequence to structure.

ABSTRACT: Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the template is deemed rather minor for identifying residues that constitute the wall of the binding cavity or those involved in G protein recognition.

SUBMITTER: de March CA

PROVIDER: S-EPMC4570547 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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G protein-coupled odorant receptors: From sequence to structure.

de March Claire A CA Kim Soo-Kyung SK Antonczak Serge S Goddard William A WA Golebiowski Jérôme J

Protein science : a publication of the Protein Society 20150622 9

Odorant receptors (ORs) are the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is available to date and atomic-level insights are likely to be obtained by means of molecular modeling. In this article, we critically align sequences of ORs with those GPCRs for which a structure is available. Here, an alignment consistent with available site-directed mutagenesis data on various ORs is proposed. Using this alignment, the choice of the ...[more]

PMID: 26044705

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