Ontology highlight
ABSTRACT:
SUBMITTER: Jackson DN
PROVIDER: S-EPMC4576022 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Jackson Desmond N DN Yang Lin L Wu ShiBiao S Kennelly Edward J EJ Lipke Peter N PN
Antimicrobial agents and chemotherapy 20150720 10
Xanthochymol and garcinol, isoprenylated benzophenones purified from Garcinia xanthochymus fruits, showed multiple activities against Candida albicans biofilms. Both compounds effectively prevented emergence of fungal germ tubes and were also cytostatic, with MICs of 1 to 3 μM. The compounds therefore inhibited development of hyphae and subsequent biofilm maturation. Xanthochymol treatment of developing and mature biofilms induced cell death. In early biofilm development, killing had the charact ...[more]