Ontology highlight
ABSTRACT:
SUBMITTER: Linhoff MW
PROVIDER: S-EPMC4583660 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Cell 20150901 1
We present ChromATin, a quantitative high-resolution imaging approach for investigating chromatin organization in complex tissues. This method combines analysis of epigenetic modifications by immunostaining, localization of specific DNA sequences by FISH, and high-resolution segregation of nuclear compartments using array tomography (AT) imaging. We then apply this approach to examine how the genome is organized in the mammalian brain using female Rett syndrome mice, which are a mosaic of normal ...[more]