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Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes.

ABSTRACT: We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited A?1-40 peptide aggregation in vitro, and protected against A?-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of A?1-40 peptide on the basis of their emission response.

SUBMITTER: Lu L

PROVIDER: S-EPMC4588514 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes.

Lu Lihua L Zhong Hai-Jing HJ Wang Modi M Ho See-Lok SL Li Hung-Wing HW Leung Chung-Hang CH Ma Dik-Lung DL

Scientific reports 20150930

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1-40 peptide on the basis of their emission response. ...[more]

PMID: 26419607

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