Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC4589224 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Wang Bruce B Zhao Ludan L Fish Matt M Logan Catriona Y CY Nusse Roel R
Nature 20150805 7564
The source of new hepatocytes in the uninjured liver has remained an open question. By lineage tracing using the Wnt-responsive gene Axin2 in mice, we identify a population of proliferating and self-renewing cells adjacent to the central vein in the liver lobule. These pericentral cells express the early liver progenitor marker Tbx3, are diploid, and thereby differ from mature hepatocytes, which are mostly polyploid. The descendants of pericentral cells differentiate into Tbx3-negative, polyploi ...[more]