Dataset Information

Repeatability of hypoxia PET imaging using [¹?F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial.

ABSTRACT:

Purpose

Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer.

Methods

Nine patients with lung cancer and ten with head and neck cancer were included in the analysis (NCT01075399). Two sequential pretreatment [(18)F]HX4 PET/CT scans were acquired within 1 week. The maximal and mean standardized uptake values (SUVmax and SUVmean) were defined and the tumor-to-background ratios (TBR) were calculated. In addition, hypoxic volumes were determined as the volume of the tumor with a TBR >1.2 (HV1.2). Bland Altman analysis of the uptake parameters was performed and coefficients of repeatability were calculated. To evaluate the spatial repeatability of the uptake, the PET/CT images were registered and a voxel-wise comparison of the uptake was performed, providing a correlation coefficient.

Results

All parameters of [(18)F]HX4 uptake were significantly correlated between scans: SUVmax (r?=?0.958, p?ConclusionRepeated hypoxia PET scans with [(18)F]HX4 provide reproducible and spatially stable results in patients with head and neck cancer and patients with lung cancer. [(18)F]HX4 PET imaging can be used to assess the hypoxic status of tumors and has the potential to aid hypoxia-targeted treatments.

SUBMITTER: Zegers CM

PROVIDER: S-EPMC4589564 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Repeatability of hypoxia PET imaging using [¹⁸F]HX4 in lung and head and neck cancer patients: a prospective multicenter trial.

Zegers Catharina M L CM van Elmpt Wouter W Szardenings Katrin K Kolb Hartmuth H Waxman Alan A Subramaniam Rathan M RM Moon Dae Hyuk DH Brunetti Jacqueline C JC Srinivas Shyam M SM Lambin Philippe P Chien David D

European journal of nuclear medicine and molecular imaging 20150702 12

<h4>Purpose</h4>Hypoxia is an important factor influencing tumor progression and treatment efficacy. The aim of this study was to investigate the repeatability of hypoxia PET imaging with [(18)F]HX4 in patients with head and neck and lung cancer.<h4>Methods</h4>Nine patients with lung cancer and ten with head and neck cancer were included in the analysis (NCT01075399). Two sequential pretreatment [(18)F]HX4 PET/CT scans were acquired within 1 week. The maximal and mean standardized uptake values ...[more]

PMID: 26136164

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