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Pharmacokinetic modeling of a novel hypoxia PET tracer [18F]HX4 in patients with non-small cell lung cancer.


ABSTRACT: BACKGROUND:[18F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [18F]HX4 kinetics and assesses the performance of simplified methods for quantification of [18F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426?±?72 MBq [18F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions. RESULTS:Best fits were obtained using the reversible two-tissue compartment model with blood volume parameter (2T4k+VB). Simplified measures correlated well with VT estimates (tumor-to-blood ratio (TBr) R 2?=?0.96, tumor-to-muscle ratio R 2?=?0.94, standardized uptake value R 2?=?0.89). CONCLUSIONS:[18F]HX4 shows reversible kinetics in tumor tissue: 2T4k+VB. TBr based on static imaging at 2 or 4 h can be used for quantification of [18F]HX4 uptake.

SUBMITTER: Verwer EE 

PROVIDER: S-EPMC5153396 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Pharmacokinetic modeling of a novel hypoxia PET tracer [<sup>18</sup>F]HX4 in patients with non-small cell lung cancer.

Verwer E E EE   Zegers C M L CM   van Elmpt W W   Wierts R R   Windhorst A D AD   Mottaghy F M FM   Lambin P P   Boellaard R R  

EJNMMI physics 20161212 1


<h4>Background</h4>[<sup>18</sup>F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [<sup>18</sup>F]HX4 kinetics and assesses the performance of simplified methods for quantification of [<sup>18</sup>F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [<sup>18</sup>F]HX4, each lasting 30 min. Several compar  ...[more]

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