Ontology highlight
ABSTRACT:
SUBMITTER: Fan XY
PROVIDER: S-EPMC4589734 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Fan Xue-Yu XY Tian Chan C Wang Hui H Xu Yin Y Ren Ke K Zhang Bao-Yun BY Gao Chen C Shi Qi Q Meng Ge G Zhang Lu-Bin LB Zhao Yang-Jing YJ Shao Qi-Xiang QX Dong Xiao-Ping XP
Scientific reports 20151001
AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy, by phosphorylating ULK1 at specific sites. A previous study demonstrated activation of the macroautophagic system in scrapie-infected experimental rodents and in certain human prion diseases, in which the essential negative regulator mTOR is severely inhibited. In this study, AMPK and ULK1 in the brains of hamsters infected with scrapie strain 263 K and in the scrapie-infected cell line SMB-S15 were analyse ...[more]