Ontology highlight
ABSTRACT:
SUBMITTER: Lee SB
PROVIDER: S-EPMC4592523 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20150917 1
Mutations in the E3 ubiquitin ligase Parkin have been linked to familial Parkinson's disease. Parkin has also been implicated in mitosis through mechanisms that are unclear. Here we show that Parkin interacts with anaphase promoting complex/cyclosome (APC/C) coactivators Cdc20 and Cdh1 to mediate the degradation of several key mitotic regulators independent of APC/C. We demonstrate that ordered progression through mitosis is orchestrated by two distinct E3 ligases through the shared use of Cdc20 ...[more]