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Design and fabrication of a metastable β-type titanium alloy with ultralow elastic modulus and high strength.

ABSTRACT: Titanium and its alloys have become the most attractive implant materials due to their high corrosion resistance, excellent biocompatibility and relatively low elastic modulus. However, the current Ti materials used for implant applications exhibit much higher Young's modulus (50 ~ 120 GPa) than human bone (~30 GPa). This large mismatch in the elastic modulus between implant and human bone can lead to so-called "stress shielding effect" and eventual implant failure. Therefore, the development of β-type Ti alloys with modulus comparable to that of human bone has become an ever more pressing subject in the area of advanced biomedical materials. In this study, an attempt was made to produce a bone-compatible metastable β-type Ti alloy. By alloying and thermo-mechanical treatment, a metastable β-type Ti-33Nb-4Sn (wt. %) alloy with ultralow Young's modulus (36 GPa, versus ~30 GPa for human bone) and high ultimate strength (853 MPa) was fabricated. We believe that this method can be applied to developing advanced metastable β-type titanium alloys for implant applications. Also, this approach can shed light on design and development of novel β-type titanium alloys with large elastic limit due to their high strength and low elastic modulus.

SUBMITTER: Guo S

PROVIDER: S-EPMC4592961 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The microstructure of trabecular bone is usually perceived as a collection of plate-like and rod-like trabeculae, which can be determined from the emerging high-resolution skeletal imaging modalities such as micro-computed tomography (?CT) or clinical high-resolution peripheral quantitative CT (HR-pQCT) using the individual trabecula segmentation (ITS) technique. It has been shown that the ITS-based plate and rod parameters are highly correlated with elastic modulus and yield strength of human trabecular bone. In the current study, plate-rod (PR) finite element (FE) models were constructed completely based on ITS-identified individual trabecular plates and rods. We hypothesized that PR FE can accurately and efficiently predict elastic modulus and yield strength of human trabecular bone. Human trabecular bone cores from proximal tibia (PT), femoral neck (FN) and greater trochanter (GT) were scanned by ?CT. Specimen-specific ITS-based PR FE models were generated for each ?CT image and corresponding voxel-based FE models were also generated in comparison. Both types of specimen-specific models were subjected to nonlinear FE analysis to predict the apparent elastic modulus and yield strength using the same trabecular bone tissue properties. Then, mechanical tests were performed to experimentally measure the apparent modulus and yield strength. Strong linear correlations for both elastic modulus (r(2) = 0.97) and yield strength (r(2) = 0.96) were found between the PR FE model predictions and experimental measures, suggesting that trabecular plate and rod morphology adequately captures three-dimensional (3D) microarchitecture of human trabecular bone. In addition, the PR FE model predictions in both elastic modulus and yield strength were highly correlated with the voxel-based FE models (r(2) = 0.99, r(2) = 0.98, respectively), resulted from the original 3D images without the PR segmentation. In conclusion, the ITS-based PR models predicted accurately both elastic modulus and yield strength determined experimentally across three distinct anatomic sites. Trabecular plates and rods accurately determine elastic modulus and yield strength of human trabecular bone.

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Design and fabrication of a metastable β-type titanium alloy with ultralow elastic modulus and high strength.

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