Ontology highlight
ABSTRACT:
SUBMITTER: Xu C
PROVIDER: S-EPMC4596771 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Xu Chunxiao C Buczkowski Kevin A KA Zhang Yanxi Y Asahina Hajime H Beauchamp Ellen M EM Terai Hideki H Li Yvonne Y YY Meyerson Matthew M Wong Kwok-Kin KK Hammerman Peter S PS
Molecular cancer therapeutics 20150723 10
Genetically engineered mouse models of lung cancer have demonstrated an important role in understanding the function of novel lung cancer oncogenes and tumor-suppressor genes identified in genomic studies of human lung cancer. Furthermore, these models are important platforms for preclinical therapeutic studies. Here, we generated a mouse model of lung adenocarcinoma driven by mutation of the discoidin domain receptor 2 (DDR2) gene combined with loss of TP53. DDR2(L63V);TP53(L/L) mice developed ...[more]