Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Melanoma
SUBMITTER: Dupuy Jean-William
LAB HEAD: Frédéric Saltel
PROVIDER: PXD028292 | Pride | 2023-05-02
REPOSITORIES: Pride
Action | DRS | |||
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F008358.dat | Other | |||
F008360.dat | Other | |||
F008364.dat | Other | |||
F008365.dat | Other | |||
F008368.dat | Other |
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Oncogene 20220323 18
Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic BRAF V600E mutation. However, the main issue with targeted therapy is the acquisition of tumor cell resistance. In a majority of resistant melanoma cells, the resistant process consists in epithelial-to-mesenchymal transition (EMT). This process called phenotype switching makes melanoma cells more invasive. Its signature is characterized by MITF low, ...[more]