Ontology highlight
ABSTRACT:
SUBMITTER: Vachon CM
PROVIDER: S-EPMC4598340 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Vachon Celine M CM Pankratz V Shane VS Scott Christopher G CG Haeberle Lothar L Ziv Elad E Jensen Matthew R MR Brandt Kathleen R KR Whaley Dana H DH Olson Janet E JE Heusinger Katharina K Hack Carolin C CC Jud Sebastian M SM Beckmann Matthias W MW Schulz-Wendtland Ruediger R Tice Jeffrey A JA Norman Aaron D AD Cunningham Julie M JM Purrington Kristen S KS Easton Douglas F DF Sellers Thomas A TA Kerlikowske Karla K Fasching Peter A PA Couch Fergus J FJ
Journal of the National Cancer Institute 20150304 5
We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting and Data System (BI-RADS) breast density were independent risk factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. We incorporated the PRS odds ratio (OR) into the Breast Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable risk and compared five-year absolute risk predictions between models using area under th ...[more]