Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.
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ABSTRACT:
SUBMITTER: Ikeda H
PROVIDER: S-EPMC4599646 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing.
Ikeda Hiroshi H Ishiguro Kazuya K Igarashi Tetsuyuki T Aoki Yuka Y Hayashi Toshiaki T Ishida Tadao T Sasaki Yasushi Y Tokino Takashi T Shinomura Yasuhisa Y
OncoTargets and therapy 20151005
A 69-year-old man was diagnosed with IgG λ-type multiple myeloma (MM), Stage II in October 2010. He was treated with one cycle of high-dose dexamethasone. After three cycles of bortezomib, the patient exhibited slow elevations in the free light-chain levels and developed a significant new increase of serum M protein. Bone marrow cytogenetic analysis revealed a complex karyotype characteristic of malignant plasma cells. To better understand the molecular pathogenesis of this patient, we sequenced ...[more]
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