Ontology highlight
ABSTRACT:
SUBMITTER: Salomon-Perzynski A
PROVIDER: S-EPMC9313382 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Salomon-Perzyński Aleksander A Barankiewicz Joanna J Machnicki Marcin M Misiewicz-Krzemińska Irena I Pawlak Michał M Radomska Sylwia S Krzywdzińska Agnieszka A Bluszcz Aleksandra A Stawiński Piotr P Rydzanicz Małgorzata M Jakacka Natalia N Solarska Iwona I Borg Katarzyna K Spyra-Górny Zofia Z Szpila Tomasz T Puła Bartosz B Grosicki Sebastian S Stokłosa Tomasz T Płoski Rafał R Lech-Marańda Ewa E Jakubikova Jana J Jamroziak Krzysztof K
Biomedicines 20220712 7
Clonal evolution drives treatment failure in multiple myeloma (MM). Here, we used a custom 372-gene panel to track genetic changes occurring during MM progression at different stages of the disease. A tumor-only targeted next-generation DNA sequencing was performed on 69 samples sequentially collected from 30 MM patients. The MAPK/ERK pathway was mostly affected with KRAS mutated in 47% of patients. Acquisition and loss of mutations were observed in 63% and 37% of patients, respectively. Four di ...[more]