Ontology highlight
ABSTRACT:
SUBMITTER: Izaguirre-Carbonell J
PROVIDER: S-EPMC4601023 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Izaguirre-Carbonell Jesus J Kawakubo Hirofumi H Murata Hiroshi H Tanabe Atsushi A Takeuchi Toshifumi T Kusayanagi Tomoe T Tsukuda Senko S Hirakawa Takeshi T Iwabata Kazuki K Kanai Yoshihiro Y Ohta Keisuke K Miura Masahiko M Sakaguchi Kengo K Matsunaga Sachihiro S Sahara Hiroeki H Kamisuki Shinji S Sugawara Fumio F
Scientific reports 20151012
SQAP is a novel and promising anticancer agent that was obtained by structural modifications from a natural compound. SQAP inhibits angiogenesis in vivo resulting in increased hypoxia and reduced tumor volume. In this study, the mechanism by which SQAP modifies the tumor microenvironment was revealed through the application of a T7 phage display screening. This approach identified five SQAP-binding proteins including sterol carrier protein 2, multifunctional enzyme type 2, proteasomal ubiquitin ...[more]