Ontology highlight
ABSTRACT:
SUBMITTER: Lepesheva GI
PROVIDER: S-EPMC4601915 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lepesheva Galina I GI Hargrove Tatiana Y TY Rachakonda Girish G Wawrzak Zdzislaw Z Pomel Sébastien S Cojean Sandrine S Nde Pius N PN Nes W David WD Locuson Charles W CW Calcutt M Wade MW Waterman Michael R MR Daniels J Scott JS Loiseau Philippe M PM Villalta Fernando F
The Journal of infectious diseases 20150415 9
Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol biosynthesis. They serve as clinical targets for antifungal azoles and are considered as targets for treatment of human Trypanosomatidae infections. Recently, we have shown that VNI, a potent and selective inhibitor of trypanosomal CYP51 that we identified and structurally characterized in complex with the enzyme, can cure the acute and chronic forms of Chagas disease. The purpose of this work was to apply the CYP51 structure/f ...[more]