Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida S
PROVIDER: S-EPMC4602043 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Yoshida Sei S Pacitto Regina R Yao Yao Y Inoki Ken K Swanson Joel A JA
The Journal of cell biology 20151005 1
The rapid activation of the mechanistic target of rapamycin complex-1 (mTORC1) by growth factors is increased by extracellular amino acids through yet-undefined mechanisms of amino acid transfer into endolysosomes. Because the endocytic process of macropinocytosis concentrates extracellular solutes into endolysosomes and is increased in cells stimulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in amino acid-dependent activation of mTORC1. Here, we show that growt ...[more]