Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.
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ABSTRACT:
SUBMITTER: Baio JE
PROVIDER: S-EPMC4608256 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.
Baio Joe E JE Schach Denise D Fuchs Adrian V AV Schmüser Lars L Billecke Nils N Bubeck Christoph C Landfester Katharina K Bonn Mischa M Bruns Michael M Weiss Clemens K CK Weidner Tobias T
Chemical communications (Cambridge, England) 20150101 2
pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface. ...[more]
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