Ontology highlight
ABSTRACT:
SUBMITTER: Song J
PROVIDER: S-EPMC4615524 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Song Juquan J Saeman Melody R MR De Libero Jana J Wolf Steven E SE
Shock (Augusta, Ga.) 20151101 5
Muscle loss accompanies severe burn; in this hyper-catabolic state, muscle undergoes atrophy through protein degradation and disuse. Muscle volume is related to the relative rates of cellular degradation and myogenesis. We hypothesize that muscle atrophy after injury is in part because of insufficient myogenesis associated with the hyper-inflammatory response. The aim of this study was to investigate the role of skeletal myogenesis and muscle cell homeostasis in response to severe burn. Twenty-e ...[more]