Ontology highlight
ABSTRACT:
SUBMITTER: Hettmer S
PROVIDER: S-EPMC4718790 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Hettmer Simone S Lin Michael M MM Tchessalova Daria D Tortorici Sara J SJ Castiglioni Alessandra A Desai Tushar T Mao Junhao J McMahon Andrew P AP Wagers Amy J AJ
Experimental cell research 20151013 1
Hedgehog (Hh) pathway activation in R26-SmoM2;CAGGS-CreER mice, which carry a tamoxifen-inducible activated Smoothened allele (SmoM2), results in numerous microscopic tumor foci in mouse skeletal muscle. These tumors exhibit a highly differentiated myogenic phenotype and resemble human fetal rhabdomyomas. This study sought to apply previously established strategies to isolate lineally distinct populations of normal mouse myofiber-associated cells in order to examine cellular heterogeneity in Smo ...[more]