Ontology highlight
ABSTRACT:
SUBMITTER: Bazzoli A
PROVIDER: S-EPMC4617380 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bazzoli Andrea A Kelow Simon P SP Karanicolas John J
PloS one 20151020 10
Protein-protein interactions are among today's most exciting and promising targets for therapeutic intervention. To date, identifying small-molecules that selectively disrupt these interactions has proven particularly challenging for virtual screening tools, since these have typically been optimized to perform well on more "traditional" drug discovery targets. Here, we test the performance of the Rosetta energy function for identifying compounds that inhibit protein interactions, when these acti ...[more]